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Allegra Information

What is Allegra?

Allegra is a non sedating antihistamine prescribed by your doctor that relieves seasonal allergy symptoms like sneezing, runny nose, and itchy, watery eyes.

How does Allegra work?

Allegra is an antihistamine. Histamine is a chemical in your body that causes allergy symptoms. Allegra blocks the effect of histamine and relieves allergy symptoms such as sneezing, runny nose, and itchy, watery eyes.

How long does it take Allegra to work?

Relief of allergy symptoms may begin at 60 minutes.

Drug Uses

Allegra is indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children 6 years of age and older. Symptoms treated effectively were sneezing, rhinorrhea, itchy nose/palate/throat, itchy/watery/red eyes.
How Taken

For seasonal allergies the recommended dose for adults and children 12 years or older is 60 mg twice daily or 180 mg once daily. Children 6-11 years of age should be given 30 mg twice daily. For chronic urticaria, adults and children 12 years or older should use 60 mg twice daily, and children 6-11 years of age should use 30 mg twice daily. Fexofenadine can be taken with or without food.
Drug Class and Mechanism

Fexofenadine is an oral, "second generation" antihistamine that is used to treat the signs and symptoms of allergy that are due to histamine. It is similar to the other second generation antihistamines loratadine (Claritin), cetirizine (Zyrtec) and azelastine (Astelin). Histamine is a chemical that is responsible for many of the signs and symptoms of allergic reactions, for example, swelling of the lining of the nose, sneezing, and itchy eyes. Histamine is released from histamine-storing cells (mast cells) and then attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals that produce the effects that we associate with allergy, e.g., sneezing. Fexofenadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of H1 receptor-containing cells by histamine. Unlike the first generation antihistamines, fexofenadine and other second-generation antihistamines do not readily enter the brain from the blood, and, therefore, they cause less drowsiness. Fexofenadine was approved by the FDA in July, 1995.

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